Magnetic Resonance Imaging in Studies of Perifocal Zone of Brain Gliomas (a Literature Review)

This review provides insight into application of modern MRI modalities including diffusion kurtosis imaging in assessment of perifocal glioma zone. Differentiation of “pure” perifocal vasogenic edema from edema infiltrated by glioma cells, as well as identification of peritumoral intact (on conventional MRI) brain matter infiltration make it possible to determine glial tumor borders more accurately. Analysis of diffusion and perfusion quantitative MR data allow determining glioma borders in areas with unaltered blood-brain barrier. There is a growing possibility to develop a personalized navigation algorithm for surgical removal of the tumor, followed by the determination of an individual plan for radiation and chemotherapy, as well as prediction of disease outcomes.