A comprehensive review on synthesis of oxazoles: research on magnetically recoverable catalysts

Oxazoles are an important class of biologically active compounds in the pharmaceutical chemistry and are considered as the main structure of many biologically active compounds. Therefore, the development of efficient and ecofriendly catalytic systems for the preparation of thiazole derivatives is a key research topic in organic synthesis. During the last decade, chemistry science especially organic synthesis witnessed a huge revolution in the field of using magnetic nanocomposites as the catalyst. Magnetic nanoparticles not only have high stability, but also their surface can be easily modified and an efficient catalyst can be prepared from this method. In addition, the most important feature of magnetic nanocatalysts is their simple separation from the reaction mixture using only an external magnet. In these years, a series of magnetic nanocatalysts were reported for the synthesis of various derivatives of oxazoles, and in this article, we are going to review these methods and mention the characteristics of these catalytic systems. Based on our complete search in the literature, this is the first review-article on the application of magnetic nanocatalysts in the synthesis of oxazole derivatives. In our opinion, this review is a good source for synthetic chemists who work in the field of synthesis of oxazole derivatives and whose research is focused on magnetic nanocatalysts.