Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut

Inflammatory bowel diseases are characterized by the chronic relapsing inflammation of the gastrointesmation is widely accepted, the metabolic consequences of chronic ER stress on the pathophysiology of epithelial cells tailored to support GSH and NADPH metabolism upon ER stress. This metabolic phenotype viral and bacterial infection and fueling experimental enteritis. Consequently, the antioxidant treatment bolism to allow proper cGAS-STING signaling and innate immune responses upon gut inflammation.