Biosynthesis of Silver, Copper, and Their Bi-metallic Combination of Nanocomposites by Staphylococcus aureus: Their Antimicrobial, Anticancer Activity, and Cytotoxicity Effect

Mohsen A. Sayed,Tahany M. A. Abd El-Rahman,H. K. Abdelsalam, Sayed M. S. Abo El-Souad, Rawan Muhammad Shady, Radwa Abdallnasser Amen, Mostafa Ahmed Zaki, Martina Mohsen, Sara Desouky,Samar Saeed, Seif Omar,Asmaa A. H. El-Bassuony

Indian Journal of Microbiology(2024)

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摘要
The present study outlines an easy, cheap, and environmentally friendly way to make Staphylococcus aureus-mediated bimetallic silver-copper nanocomposites (Ag/Cu) that can fight cancer and germs. The gram-positive S. aureus synthesized Ag, Cu, and their bi-metallic nanocomposites extracellularly. We aimed to prepare the bimetallic nanocomposite in two different ways, and we compared them in terms of characterization and biological applications. The first one is a bimetallic nanocomposite (Ag/Cub) that was made by mixing Ag and Cu metal ions in equal amounts (50:50). Then, the whole mixture was reduced. The second is the after-reduction bimetallic nanocomposite (Ag/Cua), in which each metal ion was reduced separately, and then the nanocomposites were mixed (50:50
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关键词
Bi-metallic nanoparticles,S. aureus,Cytotoxicity,Antimicrobial,Anticancer activity
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