谷歌浏览器插件
订阅小程序
在清言上使用

The investigation of the dynamics of changes in neutralizing antibody titers against type 5 adenovirus in the context of vaccination against a new coronavirus infection

I. V. Amosova,T. A. Timoshicheva, R. A. Kadyrova,Y. A. Zabrodskaya,V. S. Vakin,M. P. Grudinin, V. V. Dzytseva, M. S. Khmelevsky, D. A. Lioznov

VIROLOGY(2024)

引用 0|浏览2
暂无评分
摘要
This research focuses on analyzing the dynamics of neutralizing antibody (nAbs) titers against type 5 adenovirus (Ad5) in the adult population of Russia following vaccination against the novel coronavirus infection with recombinant adenovirus type-5 COVID-19 vaccine (CanSino Biologics, China). The impact of the Ad5 vector on nAb titers was investigated using 302 blood serum samples from individuals who received a single dose of the Ad5-nCoV vector vaccine. The research revealed that 33.8% of adults in Russia had pre-existing anti-Ad5 nAbs before the pandemic. Notably, 40% of vaccinated individuals did not exhibit an increase in nAbs titers upon receiving the Ad5-based vaccine. However, in the group with no or low titers of anti-Ad5 nAbs (1:10 -1:40), a significant 8-16-fold increase in nAb titers to Ad5 was observed.
更多
查看译文
关键词
Human adenovirus 5,Adenovirus vector,Neutralizing antibodies,Vaccination,COVID-19,Immunogenicity,Immunograph
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要