Evaluation of the Relationship Between Diabetic Nephropathy, Hemogram Parameters, and Uric Asid

Aim: Inflammation plays an important role in the development of diabetic nephropathy (DNP). In our study, we aimed to analyze the relationship between the mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), platelet -lymphocyte ratio (PLR), uric acidlymphocyte ratio (UALR), and uric acid level with early diagnosis of DNP and DNP progression. Methods: Our cross-sectional study, which is a type of observational study, included patients diagnosed with type 2 diabetes mellitus and followed in the internal medicine and nephrology clinics of our hospital. Patients were divided into four groups: Group 1: estimated glomerular filtration rate (eGFR) >60 mL/min/1.73 m(2 )and albuminuria <30 mcg/day; Group 2: eGFR >60 mL/min/1.73 m(2) and albuminuria: 30-300 mcg/day; Group 3: eGFR >60 mL/min/1.73 m(2) and albuminuria >300 mcg/day; and Group 4: eGFR <60 mL/ min/1.73 m(2) and albuminuria >300 mcg/day. Thirty-six patients were included in group 1, 38 patients in group 2, 35 patients in group 3, and 40 patients in group 4. Mean platelet volume, NLR, PLR, UALR, and uric acid levels were compared among the groups. Results: A total of 149 patients were included in the study; 57.7% were female, and the mean age was 55.2 +/- 9.2 years. Significant differences were found among the groups in terms of MPV, PLR, NLR, and UALR (p<0.001, p=0.023, <= 0.001, p<0.001, respectively). There was a negative correlation between eGFR and MPV (r=-0.218, p=0.008). While there was no relationship between eGFR and platelet values, a relationship was obtained when platelets were compared with lymphocytes (r=-0.263, p=0.002). There was a weak relationship between eGFR and neutrophil levels (r=-0.188, p=0.026), but a stronger relationship was found when neutrophil and lymphocyte values were rationed (r=-0.414, p<0.001). Conclusion: Mean platelet volume, PLR, NLR, UALR, and uric acid levels, especially MPV, can be used in the development and progression of DNP.