K2CO3 Promoted Spirocyclopropanation of Thiazole‐Derived Oxadienes via 1,4‐Addition‐Induced Dearomatization Reaction
ChemistrySelect(2024)
摘要
AbstractA K2CO3 promoted spirocyclopropanation of thiazole‐derived oxadienes with bromomalonate via 1, 4‐addition‐induced dearomatization strategy has been developed. The pathway features a broad substrate scope, operational simplicity and high degree of synthetic efficiency to afford series of functionalized spiro‐cyclopropanation frameworks in 88 %–96 % yields, which enriches the research contents of thiazole‐derived oxadienes involved reactions. All products obtained herein contain two contiguous quaternary centers and their further synthetic applications are also demonstrated.
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