Transcriptome analysis reveals resveratrol promotes lipid synthesis and induces apoptosis in Siberian sturgeon

Abstract Resveratrol, known for its antioxidant properties and ability to regulate glycolipid metabolism, has been revealed its benefit effects on the liver health of sturgeon. However, further investigation is needed to understand the specific mechanism of resveratrol's impact. In this study, we explore how resveratrol affects the liver of Siberian sturgeon at a specific concentration. The results showed that resveratrol treatment led to a significant increase in apoptosis after hepatic lipid synthesis, but did not activate the antioxidant NRF2/KEAP1 pathway or enhance antioxidant enzyme activity. Transcriptomics analysis also revealed significant changes in regulatory pathways related to glycolysis, including the PPAR signaling pathway, Insulin signaling pathway, Fatty acid biosynthesis, and Glycolysis/Gluconeogenesis. These findings highlight the close relationship between resveratrol and glycolipid metabolism. Moreover, the study demonstrated that high concentrations of resveratrol can have physiological toxicity to the liver of Siberian sturgeon, providing valuable insights for future research on fish feed additives dosage.