Hippocampal CA3–CA1 synaptic network model of memory
Nonlinear Dynamics(2024)
摘要
A synaptic network model is proposed to characterize both short-term and long-term memory. The model describes the calcium concentration-dependent bistability of CaMKII phosphorylation levels and the transition of CaMKII between DOWN and UP states under different stimulation protocols. Numerical results demonstrate that short-term memory can be characterized by a trajectory tending to zero, while long-term memory can be characterized by a heteroclinic trajectory based on the principle of winnerless competition. Additionally, the results suggest that the model forms memories more efficiently with faster and longer training.
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关键词
Memory,Hippocampus,Network,AMPARs
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