Immunobiology and treatment of cutaneous T-cell lymphoma
EXPERT REVIEW OF CLINICAL IMMUNOLOGY(2024)
摘要
IntroductionPrimary cutaneous T cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas derived from skin-homing T cells. These include mycosis fungoides and its leukemic variant Sezary syndrome, as well as the CD30+ lymphoproliferative disorders.Areas CoveredIn this review, we provide a summary of the current literature on CTCL, with a focus on the immunopathogenesis and treatment of mycosis fungoides and Sezary syndrome.Expert OpinionRecent advances in immunology have provided new insights into the biology of malignant T cells. This in turn has led to the development of new therapies that modulate the immune system to facilitate tumor clearance or target specific aspects of tumor biology.
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关键词
Cutaneous T cell lymphoma,CTCL,mycosis fungoides,Sezary syndrome,cutaneous oncology,immunotherapy
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