A novel combination of machine learning models and metaheuristic algorithm to predict important parameters of twin screw wet granulation process

Twin screw granulation (TSG) has recently been emerged as a novel approach for the continuous wet granulation of fine particles (i.e., powders) in the pharmaceutical industry. The presence of brilliant advantages like the ability of operation at very low liquid concentrations and excellent product consistency has made this technique promising. Except positive points, the existence of major challenges like scalability and flexibility in the processing regimes has enhanced the importance of deeper investigations towards true recognition of this process. The central aim of this theoretical article is to develop the modeling process of TSG employing four machine learning models and one metaheuristic algorithms in a hybrid approach. Screw speeds, material throughputs, liquid binder (water)-to-solid ratios, and screw configurations are known as important parameters of TSG process, which were validated via their comparison with the obtained experimental data. GBR, SGD, and SVR were finally selected for 3 targets with their best combinations of hyper-parameters employing FA. The output is based on d-values (d10, d50, d90) for the granulate particle size distribution (PSD). Final models have R2 scores of 0.919, 0.960, and 0.877 for d10, d50, d90 outputs, respectively.