Sustainable continuous flow synthesis of -aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines

In this work we report a waste-minimized continuous flow process for the synthesis of beta-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions. The greenness of the process is harnessed by the use of flow technology for handling a biphasic segmented flow and the use of an inline liquid-liquid separator allowing the recovery of both the eco-friendly organic solvent (CPME) and the reusable acidic aqueous phase.