Two New Furanones Isolated from Coptis deltoidea Rhizome

Two undescribed furanones (1-2) were isolated from Coptis deltoidea rhizome. HRESIMS, NMR and ECD calculations were used to ascertain their structures. Based on the inflammation cell model of RAW264.7 macrophage which induced by lipopolysaccharides (LPS), RNA-Seq was used to reveal the biological activity of 1. According to the findings, 1 dramatically changed the genes expression profile of the inflammatory cell model produced by LPS in RAW264.7 cells which indicated that it had potential anti-inflammatory activitiy.