Recent Advancement of Benzofuran in Treatment of Alzheimer's Disease

Alzheimer's disease is a neurodegenerative disease that impairs motor and cognitive function it is spreading very quickly in the current scenario with a male:female ratio between 1:2 to 1:5 due to various causes associated with it which include education, diet and nutrition, sleep and cardiac rhythm and head trauma etc. Previously available drugs like tacrine failed to prove their efficacy and later were withdrawn from the market due to excess toxicity, lower solubility, and slow bioavailability. Among them, benzofuran-based drugs make a significant contribution because they are one of the important pharmacophores found both synthetically and naturally in heterocyclic compounds, with a wide range of therapeutic applications in the field of drug discovery that offers many opportunities for further improvement in anti-Alzheimer agents by acting on numerous prominent receptors. So, this article focuses on various benzofuran derivatives and their advancement in the treatment of Alzheimer's disease with a summary of the synthesis of benzofuran and benzofuran-based derivatives which assist scientists in developing successful medications with the necessary pharmacological action.