Pharmacokinetic enhancement of marbofloxacin by alpha-1-monolaurin pre-treatment in broiler chickens

The present study investigated the prospect of improvement in pharmacokinetic (PK) parameters of marbofloxacin due to alpha-1-monolaurin pre-treatment in broiler chickens. Two groups of broilers were administered a single oral dose of marbofloxacin (5.00 mg kg -1 body weight): Group -I without pre-treatment and Group -II with alpha-1-monolaurin pre-treatment (4.00 g kg -1 feed for 10 days). Blood sampling was done periodically for both groups and plasma marbofloxacin concentrations were determined using ultra -high performance liquid chromatography. Pharmacokinetic parameters using non -compartmental modelling approach were calculated with the PKSolver software. Statistical analysis revealed significant differences in plasma marbofloxacin concentrations between the two groups at 1, 2, and 24 hr. Group -II birds exhibited a higher mean maximum plasma concentration (2.43 mu g mL-1) at an earlier time (Tmax: 1.38 hr) compared to Group -I. The plasma concentrations of marbofloxacin were maintained above 0.10 and 0.18 mu g mL-1 up to 24 hr in Group -I and Group -II broilers, respectively. Significant differences were observed in PK parameters such as the area under the curve and total body clearance. The mean relative oral bioavailability of Group -II birds compared to Group -I was 119.61%. The findings of the study provided evidence of PK parameters enhancement of marbofloxacin in the alpha-1-monolaurin pre-treated group. The calculated PK-pharmacodynamic indices for marbofloxacin predicted clinical efficaciousness in the broiler chickens. (c) 2024 Urmia University. All rights reserved.