Synthesis of drug-loaded H-ZIF-8@CaCO3-PEG nanocarrier for synergistic therapy
INORGANIC CHEMISTRY COMMUNICATIONS(2024)
摘要
In this study, we synthesized DOX-loaded H-ZIF-8@CaCO3-PEG nanocarrier, which combined with calcium overload and photothermal therapy (PTT) for synergistic therapy. The nanocarrier comprised a PEG modified calcium carbonate (CaCO3) shell and a hollow imidazolate zeolite skeleton (H-ZIF-8) core, in which the chemotherapy drug doxorubicin hydrochloride (DOX) and photosensitizer indocyanine green (ICG) were simultaneously co -loaded. In vitro cellular experiments revealed that the lethality of DOX&ICG@H-ZIF- 8@CaCO3-PEG against tumor cells was significantly higher than that of the single chemotherapy owing to the combination with chemotherapy and photothermal therapy as well as calcium overloading. This drug -loaded nanocarrier exhibits notable characteristics such as exceptional stability, elevated drug loading capacity and efficient release of the loaded drug, which provides a promising perspective for efficient synergistic therapy.
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关键词
H-ZIF-8,Drug co -loading,Calcium overload,Chemotherapy,PTT,Synergistic therapy
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