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Effect of azomethine group containing compounds on gene profiles in Wnt and MAPK signal patterns in lung cancer cell line: In silico and in vitro analyses

Tugba Agbektas,Cemile Zontul,Alpaslan Ozturk,Alakbar Huseynzada,Rana Ganbarova,Ulviyya Hasanova,Gulcihan Cinar,Ayca Tas,Savas Kaya,Samir Chtita,Yavuz Silig

Journal of Molecular Structure（2023）

Cited 1|Views15
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Abstract
•Some new organic compounds were synthesized.•Their cytotoxic effect and gene expression profiles were investigated via experimental tools.•DFT calculations and Molecular Docking analyses supported the experiments made.
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Key words
Lung cancer,Azomethine group-containing compounds,Cytotoxicity,Wnt signal path,MAPK signal path,Molecular docking,Gene expression
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