Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity

•PSD-95 overexpression blocks NMDA receptor dependent ion-flux independent LTD.•This property distinguishes ion-flux dependent and independent forms of LTD.•Ion-flux independent LTD could enhance pruning in synapses with less PSD-95.•Different PSD-95 expression in mice and rats may reconcile conflicting LTD studies.