Evaluation of high temporal resolution magnetic resonance imaging of the liver with gadoxetate disodium in combination with compressed sensing and parallel imaging under single breath-holding using a 1.5-T magnetic resonance system

Background This study aimed to determine the optimal scan time for high temporal resolution magnetic resonance (MR) imaging of the liver with gadoxetate disodium injection in combination with compressed sensing (CS) and parallel imaging (PI) techniques under single breath-holding using a 1.5-T MR system. Methods Sixty-two participants underwent multiple arterial phases of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the liver with gadoxetate disodium using fat-suppressed GRE T1-weighted imaging—liver acquisition with volume acceleration (LAVA)—in combination with CS and PI using a 1.5-T MR system. Forty-six and 22 participants underwent 6-s and 10-s scans, respectively. Pre-contrast, multiple arterial, portal venous, and hepatobiliary phase images were acquired. Two radiologists evaluated the visual scores for the outline of the liver, inferior right hepatic vein (IRHV), right portal vein, right hepatic artery, appropriateness of the arterial phase, and overall image quality using a 4- or 5-point scale. Results The overall image quality and the image quality of the outline of the liver in the pre-contrast and arterial phases and IRHV in the pre-contrast phase were significantly better ( P < 0.05) in the 10-s scan group than those in the 6-s scan group. No significant difference was observed between the two groups in terms of the appropriateness of the arterial phase (obtaining the optimal arterial phase) ( P = 0.731). Conclusions A 10-s scan protocol is recommended for high temporal resolution DCE-MRI of the liver with gadoxetate disodium injection in combination with CS and PI under single breath-holding using a 1.5-T MR system.