Efficacy of dalfampridine in neuromyelitis optica spectrum disorder: A pilot study

Objective To assess the efficacy of dalfampridine in patients with neuromyelitis optica spectrum disorder.Methods We included 15 consecutive patients, who were started on a treatment of dalfampridine 10 mg twice daily for 2 weeks. Efficacy assessment was based on walking ability improvement using Timed-25-Foot Walk and 12-item Multiple Sclerosis Walking Scale tests.Results The mean Timed-25-Foot Walk score was reduced from 14.8 (+/- 2.4) to 11.3 (+/- 1.9) seconds (p = 0.01). The mean score on the 12-item Multiple Sclerosis Walking Scale was reduced from 41.2 (+/- 3.5) to 31.4 (+/- 3.2) (p = 0.004).Conclusion Dalfampridine seems to be useful for symptomatic treatment of walking impairment in neuromyelitis optica spectrum disorder.