New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292

Two new antimalarial compounds, named prenylpyridones A ( 1 ) and B ( 2 ), were discovered from the actinomycete cultured material of Streptomyces sp. RBL-0292 isolated from the soil on Hamahiga Island in Okinawa prefecture. The structures of 1 and 2 were elucidated as new iromycin analogs having α-pyridone ring by MS and NMR analyses. Compounds 1 and 2 showed moderate in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC 50 values ranging from 80.7 to 106.7 µM.