Caffeine intervention after abstinence does not alter cognitive parameters in premenstrual syndrome women regardless of CYP1A2 genotype

This study aimed to evaluate the effect of caffeine on cognitive parameters in premenstrual syndrome women of childbearing age undergoing caffeine withdrawal, observing the influence of cytochrome P450 enzyme isozyme 1A2 genotypes. This is a crossover study with 26 women (all participants) grouped according to genotype (17 AA and 9 AC/CC). The cognitive assessment was carried out before and after caffeine or placebo. A significant increase in attention was showed both after placebo and caffeine administration, however, no statistical difference was observed between caffeine and placebo groups. This occurred both for all participants and in the genotype groups. Working memory was improved for all participants, and in the AC/CC group after placebo ingestion; the same did not occur after caffeine intake. In the AA group, no significant changes were observed for placebo or caffeine. Caffeine does not promote effects on cognitive performance in premenstrual syndrome women after caffeine abstinence.