VMAT structures reveal exciting targets for drug development.
Trends in pharmacological sciences(2024)
摘要
Vesicular monoamine transporter (VMAT)-2 has a crucial role in the neurotransmission of biogenic amines. Recently, Dalton et al., Pidathala et al., Wu et al., and Wang et al. individually reported cryo-electron microscopy (EM) structures of human VMAT2, offering opportunities for developing improved therapeutics and deep insights into the functioning of this protein.
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关键词
neurotransmitter transporter,cryo-EM structure,synaptic vesicles,neurotransmission
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