Two new cassane diterpenoids from the seed kernels of Caesalpinia sinensis

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH(2024)

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Abstract
Two new cassane diterpenoids, sucupiranin MN (1) and sucupiranin ML (2), together with two known compounds sucutinirane C (3) and deacetylsucutinirane C (4) were isolated from the seed kernels of Caesalpinia sinensis. Their structures were elucidated by means of analysis of comprehensive spectroscopic data, especially HRESIMS and 1D/2D NMR spectroscopy. Compounds 1-4 are typical furan-type cassane derivatives with an aromatized C ring. Biological evaluation revealed that compounds 1-4 at the concentration of 10 mu M could inhibit the overproduction of NO in LPS-stimulated RAW 264.7 macrophages. [Graphical abstract]
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Key words
Leguminosae,Caesalpinia sinensis,cassane diterpenoids,C ring aromatized,anti-inflammatory activity
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