A new lignan from Heynea trijuga

In order to study the chemical constituents from the branches and leaves of Heynea trijuga, silica gel, MCI, C18, Sephadex LH-20 and preparative HPLC were applied for the isolation and purification of the constituents. The structures were identified by physicochemical properties and spectrum data. The results were as follows: (1) Six compounds were obtained from methanol extracts of H. trijuga, their structures were identified as heynealigan A (1), 3β,21-dihydroxy-24-methylenecycloartane (2), 3-oxo-threo-23,24,25-trihydroxytirucall-7-ene (3), 16-dehydeoxy-23β-hydroxyliasenin F (4), ergost-5, 24(28)-diene-3β, 23S-diol (5), 7α-hydrositosteol (6). (2) Compound 1 was a new lignan, compounds 2-4 were triterpenoids, compounds 5 and 6 were steroids, and compounds 2-5 were isolated from this plant for the first time. This study provides scientific basis for the rational development and utilization of T. connaroides.