Spinal astroblastoma, MN1 altered in 3-year-old child: An uncommon tumor at an unusual site

NEUROPATHOLOGY(2024)

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摘要
Astroblastoma is an uncommon circumscribed glial tumor mostly involving the cerebral hemisphere. The characteristic molecular alteration is meningioma (disrupted in balanced translocation) 1 (MN1) rearrangement. No definite World Health Organization grade has been assigned as both low- and high-grade tumors are known to occur. Tumors in the spine are extremely rare; to date only three cases have been reported in the literature. A vigilant microscopy and ancillary testing aid in diagnosis when the tumors present in unusual locations, as in our case. The prompt differentiation of this tumor from its mimickers is a mandate as modalities of management are different and not clearly established.
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关键词
ependymoma,fluorescence in situ hybridization (FISH),gross total resection (GTR),meningioma (disrupted in balanced translocation) 1 (MN1),spinal astroblastoma
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