Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update
MOLECULAR NUTRITION & FOOD RESEARCH(2024)
摘要
The discovery of metabolically active brown adipose tissue (BAT) in human adults and the worldwide increase in obesity and obesity-related chronic noncommunicable diseases (NCDs) has made BAT a therapeutic target in the last two decades. The potential of BAT to oxidize fatty acids rapidly and increase energy expenditure inversely correlates with adiposity, insulin and glucose resistance, and cardiovascular and metabolic diseases. Currently, BAT is recognized by a new molecular signature; several BAT-derived molecules that act positively on target tissues have been identified and collectively called batokines. Bioactive compounds present in foods are endowed with thermogenic properties that increase BAT activation signaling. Understanding the mechanisms that lead to BAT activation and the batokines secreted by it within the thermogenic state is fundamental for its recruitment and management of obesity and NCDs. This review contributes to recent updates on the morphophysiology of BAT, its endocrine role in obesity, and the main bioactive compounds present in foods involved in classical and nonclassical thermogenic pathways activation. The discovery of metabolically active brown adipose tissue (BAT) in adults and the global obesity epidemic have made BAT a therapeutic focus. BAT now has a new molecular signature, with identified molecules called batokines. Certain food compounds enhance BAT activation. This review covers BAT's physiology, its role in obesity, and food compounds that activate thermogenesis. image
更多查看译文
关键词
brown adipose tissue,chronic non-communicable diseases,functional foods,obesity,thermogenesis
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要