Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA-A3303 and HLA-DPB10501.

Yaqing Shu,Renliang Huang,Qihui Li,Yi Lu,Junping Yin,Huilu Li, Zhike Lan, Xiujun Zheng,Jinlong Ye,Youming Long,Zhanhang Wang,Li Xiao,Qiaomiao Zhou,Xu Liu,Ying Fu,Hao Chen, Juanjuan Chen,Yanxia Zhou, Juan Zhou, Liting Zhang, Jing Zhou,Ying Jiang,Fuhua Peng,Zhengqi Lu,Frank Petersen,Wei Qiu,Xinhua Yu

Annals of neurology（2024）

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摘要

We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA-A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.32-3.06, p = 0.00072, padj. = 0.046) and HLA-DBP1*0501 (OR = 0.51, 95% CI = 0.36-0.71, p = 0.000048, padj. = 0.0062). Moreover, HLA-A*3303 carriers with the disease had a longer hospital stay (p = 0.0005) than non-carriers. This study for the first time provides evidence for a role of genetic factor in the development of autoimmune GFAP astrocytopathy. ANN NEUROL 2024;95:901-906.

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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA-A*3303 and HLA-DPB1*0501.

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA-A3303 and HLA-DPB10501.