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Discovery of ASP6918, a KRAS G12C Inhibitor: Synthesis and Structure–activity Relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one Derivatives As Covalent Inhibitors with Good Potency and Oral Activity for the Treatment of Solid Tumors

Tomoyoshi Imaizumi,Itsuro Shimada, Yuki Satake, Shohei Yamaki,Takanori Koike,Takahiro Nigawara,Osamu Kaneko,Y. Amano,Kenichi Mori,Yosuke Yamanaka,Ayako Nakayama,Yoshihiro Nishizono,Masashi Shimazaki, Takahiro Nagashima,Kazuyuki Kuramoto

Bioorganic & Medicinal Chemistry（2023）

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