Applications and Potentials of a Silk Fibroin Nanoparticle Delivery System in Animal Husbandry

Simple Summary Silk fibroin (SF) from silkworms is exceptionally biocompatible and biodegradable. The nanoparticle delivery systems constructed with SF can improve drug delivery and enhance action efficiency. This review outlines the various nanoparticle delivery systems, focusing on the application and potential of eco-friendly SF as a delivery system in animal husbandry. The aim is to provide theoretical references for the further development and application of SF in animal husbandry.Abstract Silk fibroin (SF), a unique natural polymeric fibrous protein extracted from Bombyx mori cocoons, accounts for approximately 75% of the total mass of silk. It has great application prospects due to its outstanding biocompatibility, biodegradability, low immunogenicity, and mechanical stability. Additionally, it is non-toxic and environmentally friendly. Nanoparticle delivery systems constructed with SF can improve the bioavailability of the carriers, increase the loading rates, control the release behavior of the deliverables, and enhance their action efficiencies. Animal husbandry is an integral part of agriculture and plays a vital role in the development of the rural economy. However, the pillar industry experiences a lot of difficulties, like drug abuse while treating major animal diseases, and serious environmental pollution, restricting sustainable development. Interestingly, the limited use cases of silk fibroin nanoparticle (SF NP) delivery systems in animal husbandry, such as veterinary vaccines and feed additives, have shown great promise. This paper first reviews the SF NP delivery system with regard to its advantages, disadvantages, and applications. Moreover, we describe the application status and developmental prospects of SF NP delivery systems to provide theoretical references for further development in livestock production and promote the high-quality and healthy development of animal husbandry.