A non-peptide-based fluorescent probe capable of sensitively visualizing asparagine endopeptidase

Kang Li, Yanxian Hou, Jinliang Han,Chengyuan Lv,Wenkai Liu,Jianjun Du,Wen Sun,Jiangli Fan,Xiaojun Peng

CHEMICAL COMMUNICATIONS（2024）

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摘要

The non-peptide-based fluorescent probe QMC11 is capable of specifically targeting asparagine endopeptidase (AEP) and imaging cellular endogenous AEP. The motion of the probe can be restricted by AEP to activate fluorescence while keeping a low background signal. A sensitive and facilely synthesized fluorescent probe, QMC11, was designed for visualizing AEP.

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