Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor

Prashil Gondane, Sakshi Kumbhakarn, Pritiprasanna Maity,Kausik Kapat

BIOENGINEERING-BASEL(2024)

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摘要
Preterm birth (PTB) is the primary cause of neonatal mortality and long-term disabilities. The unknown mechanism behind PTB makes diagnosis difficult, yet early detection is necessary for controlling and averting related consequences. The primary focus of this work is to provide an overview of the known risk factors associated with preterm labor and the conventional and advanced procedures for early detection of PTB, including multi-omics and artificial intelligence/machine learning (AI/ML)- based approaches. It also discusses the principles of detecting various proteomic biomarkers based on lateral flow immunoassay and microfluidic chips, along with the commercially available point-of-care testing (POCT) devices and associated challenges. After briefing the therapeutic and preventive measures of PTB, this review summarizes with an outlook.
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关键词
preterm birth (PTB),prelabor rupture of membrane (PROM),biomarkers,lateral flow immunoassay (LFIA) device,microfluidics,multi-omics
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