Structural Basis of TMPRSS2 Zymogen Activation and Recognition by the HKU1 Seasonal Coronavirus

Ignacio Fernandez,Nell Saunders,Stephane Duquerroy,William H. Bolland, Atousa Arbabian,Eduard Baquero,Catherine Blanc,Pierre Lafaye,Ahmed Haouz,Julian Buchrieser,Olivier Schwartz,Felix A. Rey

Cell（2024）

Cited 6|Views24

Key words

virus entry,3D structure,human coronaviruses,entry receptor,spike maturation,serine protease activation,zymogen triad,TMPRSS2 inhibition,androgen-regulated proteases

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