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Excitotoxicity and ALS : New therapy targets an old mechanism

Hannah Louise Smith,Helena Chaytow,Thomas Henry Gillingwater

CELL REPORTS MEDICINE（2024）

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Abstract
Excitotoxicity-induced cell death in motor neurons is a major therapeutic target for amyotrophic lateral sclerosis (ALS). Yan et al.1 present a novel compound to specifically disrupt extra-synaptic NMDAR complexes, extending the lifespan of the SOD1G93A ALS mouse and ameliorating cell death.
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