Exploring the Therapeutic Potential of Lawsone and Nanoparticles in Cancer and Infectious Disease Management.

Haider Kamil Zaidan, Hanadi Had Jasim Al-Khafaji, F Al-Dolaimy, Shaymaa Abed Hussein, Rand Otbah Farqad, Daha Thabit, Ashwaq Talib Kareem,Montather F Ramadan,Sarah A Hamood,Ahmed Hussien Alawadi,Ali Alsaalamy

Chemistry & biodiversity(2024)

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摘要
Lawsone, a naturally occurring compound found in henna, has been used in traditional medicine for centuries due to its diverse biological activities. In recent years, its nanoparticle-based structure has gained attention in cancer and infectious disease research. This review explores the therapeutic potential of lawsone and its nanoparticles in the context of cancer and infectious diseases. Lawsone exhibits promising anticancer properties by inducing apoptosis and inhibiting cell proliferation, while its nanoparticle formulations enhance targeted delivery and efficacy. Moreover, lawsone demonstrates significant antimicrobial effects against various pathogens. The unique physicochemical properties of lawsone nanoparticles enable efficient cellular uptake and targeted delivery. Potential applications in combination therapy and personalized medicine open new avenues for cancer and infectious disease treatment. While clinical trials are needed to validate their safety and efficacy, lawsone-based nanoparticles offer hope in addressing unmet medical needs and revolutionizing therapeutic approaches.
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