Ordered mesoporous silica microspheres for supercritical fluid chromatography

Herein, silica microspheres with ordered mesopores are synthesized and applied as a stationary phase for supercritical fluid chromatography (SFC). The excellent particle monodispersity and pore orderliness coupled with the rapid analytes diffusion of the supercritical fluid lead to an ultra-high column efficiency of 340 000 plate per m. Ultra-high efficiency can be achieved by combining the advantages of high diffusion efficiency of SFC and pore orderliness of OMS.