Dual-Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

Dandan Chu,Mengyang Zhao,Shisong Rong, Wonho Jhe,Xiaolu Cai,Yi Xiao, Wei Zhang,Xingchen Geng,Zhanrong Li,Xingcai Zhang,Jingguo Li

Nano-Micro Letters（2024）

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摘要

Highlights A dual-atom nanozyme (DAN) was successfully prepared based on Fe and Mn bimetallic single-atom embedded in N-doped carbon material and modified with hydrophilic polymer. The DAN possess excellent enzyme catalytic activity and attenuate dramatically inflammation by inhibiting the reactive oxygen species (ROS)/NLRP3 signal axis. The DAN break the vicious cycle in dry eye disease and is a potential strategy for treating dry eye disease.

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关键词

Dry eye disease,DAN,Dual-atom nanozyme,Vicious cycle,NLRP3 inflammasome,Nanomedicine

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