Effect of the social environment on olfaction and social skills in WT and mouse model of autism
arxiv(2023)
摘要
Autism spectrum disorders are complex, polygenic and heterogenous
neurodevelopmental conditions, imposing a substantial economic burden. Genetics
are influenced by the environment, specifically the social experience during
the critical neurodevelopmental period. Despite efficacy of early behavior
interventions targeted specific behaviors in some autistic children, there is
no sustainable treatment for the two core symptoms: deficits in social
interaction and communication, and stereotyped or restrained behaviors or
interests. In this study, we investigated the impact of the social environment
on both wild-type (WT) and Shank3 knockout (KO) mice, a mouse model that
reproduces core autism-like symptoms. Our findings revealed that WT mice raised
in an enriched social environment maintained social interest towards new
conspecifics across multiple trials. Additionally, we observed that 2 hours or
chronic social isolation induced social deficits or enhanced social interaction
and olfactory neuron responses in WT animals, respectively. Notably, chronic
social isolation restored both social novelty and olfactory deficits, and
normalized self-grooming behavior in Shank3 KO mice. These results novel
insights for the implementation of behavioral intervention and inclusive
classrooms programs for children with ASD.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要