Optimization and Validation of a UPLC-MS/MS Assay for Simultaneous Quantification of 2,8-Dihydroxyadenine, Adenine, Allopurinol, Oxypurinol and Febuxostat in Human Plasma.

Unnur A. Thorsteinsdottir,Hrafnhildur L. Runolfsdottir,Finnur F. Eiriksson,Inger M. Sch. Agustsdottir,Vidar O. Edvardsson,Runolfur Palsson,Margret Thorsteinsdottir

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES（2024）

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关键词

Adenine phosphoribosyltransferase (APRT) deficiency,Rare kidney stone diseases,Diagnosis,Pharmacotherapy monitoring,Design of experiments (DoE),Validation,Clinical mass spectrometry

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