Organophotocatalytic -deuteration of unprotected primary amines via H/D exchange with D₂O

We report a straightforward H/D exchange method for the synthesis of alpha-deuterated primary amines from a diverse set of primary amines with high levels of deuteration and chemo- and site selectivity and preparative utility. This cost-effective strategy enables the direct conversion of primary amines to alpha-deuterated counterparts using D2O as the deuterium source under mild reaction conditions without requiring additional functionality manipulation and with minimal byproduct production.