Electro-induced O-S bonding reaction targeting biological macromolecules

This study endeavors to explore the utilization of aromatic sulfinates as bioconjugation handles, addressing the challenges associated with the modification of aromatic amino acid residues (Tyrosine) and paving the way for innovative approaches to biomolecule functionalization. Mechanistic investigations have indicated the potential involvement of a radical mechanism in the reaction. This study endeavors to explore the utilization of aromatic sulfinates as bioconjugation handles, addressing the challenges associated with the modification of Tyrosine and paving the way for innovative approaches to biomolecule functionalization.