Copper-Catalyzed C(sp²)-C(sp²) Bond Formation via Single C(sp²)-H Activation

This review provides a comprehensive overview and evaluation of the studies conducted over the past 15 years into copper catalyzed reactions for C(sp(2))-C(sp(2)) bond formation via C(sp(2))-H activation. The investigations encompass a wide array of starting materials and substrates. The range of substrates studied has been broadened to encompass C-H activation of aryls, heteroaryls, and alkenyl groups. Furthermore, in some cases only catalytic amounts of copper salts were required to drive the challenging C-H functionalization, indicating a promising avenue for future research.