Estrogen-related receptor alpha: A novel perspective on skeletal, muscular, and vascular systems

Estrogen-related receptor alpha can significantly affect cell metabolism and play key regulatory roles in healthy and diseased organisms. ERR alpha is also related to the onset and progression of various cancer types. ERR alpha is primarily expressed in metabolically active tissues and regulates the transcription of metabolic genes in such tissues. It coordinates metabolism and energy demand, affects osteoblasts, osteoclasts, and chondrocytes, promotes muscle regeneration, participates in angiogenesis, and regulates cell aging. In this study, the literature related to the identification of ERR alpha in skeletal, muscular, and vascular systems was reviewed to further elucidate this receptor.