Ruthenium compounds: Are they the next-era anticancer agents?

APPLIED ORGANOMETALLIC CHEMISTRY(2024)

引用 0|浏览4
暂无评分
摘要
This study focuses on the cytotoxic activity of ruthenium(II) complexes, denoted as Ru1-8, which exhibit coordination with nitrogen (amine and amide), oxygen, and sulfur donor atoms, coupled with aryl and aliphatic wingtips. Specifically, the complexes were evaluated for their impact on the MCF-7 breast cancer cell line. A systematic exploration of various parameters, including solubility, donor atom type, metal number, carbon chain length, aromatic ring presence, and molecular weight, was conducted to discern their influence on cytotoxic activity. The investigation involved assessing the cell viability across five concentrations (100, 50, 25, 10, and 5 mu M) for five distinct monometallic and three bimetallic ruthenium complexes. Notably, Ru3, characterized by an extended carbon chain length (dodecyl) and favorable oil solubility facilitating cellular membrane penetration, demonstrated particularly promising results with the IC50 value of 1.03 mu M. This research underscores the critical role of ligand design in shaping the cytotoxic potential of ruthenium(II) complexes and emphasizes the suitability of the Ru(II) p-cymene complexes, as demonstrated by their robust activity against breast cancer in this specific investigation. Novel Ru(II) arene complexes were prepared. The cytotoxic activities of these complexes were investigated on MCF-7 cell line. The structure-activity relationships for the complexes containing Namine/Namine, Namine/Namide, Namide/Oamide, and Namide/Sthiolate/Sthiolate-chelating ligands were investigated. The promising results were obtained. image
更多
查看译文
关键词
anticancer agents,antineoplastic agents,chelating ligand,cytotoxicity,MCF-7,ruthenium(II) arene complexes
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要