Incidental finding of [⁹⁹mTc]Tc-MIBI uptake in a post-radiotherapy breast without recurrence of cancer

The oncophilic nature of [Tc-99m]Tc-MIBI makes this radiopharmaceutical useful in cancer diagnostics, with particular emphasis on breast cancer. Increased uptake of [Tc-99m]Tc-MIBI in tests performed for non-oncological indications always raises the suspicion of its neoplasmatic character and requires further clinical diagnostics, which is especially justified in patients with a previous history of cancer. However, the presented case illustrates that focally increased uptake of [Tc-99m]Tc-MIBI is not always associated with the presence of cancer cells and may result from post-therapeutic changes.