Asymmetric Synthesis of Tertiary -Hydroxylation-Cyclopentanones via Synergetic Catalysis of Chiral-at-Metal Rhodium(III) Complexes/Pyrrolidine
JOURNAL OF ORGANIC CHEMISTRY(2023)
摘要
Catalytic and asymmetric domino Michael/aldol reaction of 1,2-dicarbonyl compounds with alpha,beta-unsaturated ketones under the synergetic catalysis of chiral-at-metal rhodium complexes and pyrrolidine to deliver tertiary alpha-hydroxylation-cyclopentanones (45-89% yields with 81-99% ee and up to >20:1 dr) bearing three contiguous stereogenic centers had been established. Moreover, the scalability and practical utility of this protocol were well demonstrated by employing a gram-scale reaction and some representative transformations.
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