Off-label: The results of adjunctive bone morphogenetic protein for challenging femur fractures; a review of two cases
Trauma Case Reports(2024)
Abstract
Background
Although bone morphogenetic proteins (BMPs) are used as an adjunct to promote healing, they may have unintended effects such as heterotopic ossification (HO). The literature is limited regarding the effect of using off-label BMPs for femur fractures.
Case presentation
We report two outcomes after off-label use of BMPs for the treatment of femur fractures and propose a possible explanation for the difference.
Conclusions
BMPs are critical osteoinductive factors in injured bone and muscle that facilitate bony healing. However, it may be important to recognize the potentially negative effects of adding BMP to bone graft material in certain cases to stimulate bone repair. We hope this case series helps surgeons consider the risks and benefits of using BMP for femur fractures, and therefore to decide with caution when BMP is indicated.
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Key words
Bone morphogenetic protein (BMP),Off-label use,Femur fracture,Heterotropic ossification
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