Reply to comments by Dr. Ali Shayanfar

Several clarifications are made pertaining to the study on the cocrystallization of 5-fluorouracil (5 -FU) and gallic acid (GA). Dr. Shayanfar's perspective in the solubility and biological activity of cocrystals is recognized, and his insightful guidance on solubility determination methodologies is greatly appreciated. A misconception concerning the cytotoxicity assay methodology in the Shayanfar's comments is addressed. Furthermore, the stability of the 5 -FU -GA cocrystal during solubility measurement is highlighted, as evidenced by XRD analysis of residual solids. Lastly, the independence of the elevated cytotoxicity of the cocrystal from 5 -FU solubility is deliberated, aligning with preceding research outcomes.