Structure- and Machine Learning-Guided Engineering Demonstrate That a Non-Canonical Disulfide in an Anti-Pd-1 Rabbit Antibody Does Not Impede Antibody Developability

Wei-Ching Liang,Hongkang Xi,Dawei Sun,Luigi D'Ascenzo,Jonathan Zarzar,Nicole Stephens,Ryan Cook, Yinyin Li,Zhengmao Ye,Marissa Matsumoto,Jian Payandeh,Matthieu Masureel,Yan Wu

mAbs（2024）

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Complementarity determining regions (CDRs),disulfide bond,humanization,ML/AI-guided protein design,Programmed cell death 1 (PD-1),Rabbit monoclonal antibody (mab)

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