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Host-microbial crosstalk relies on “tuft” love

Stefania De Santis,Theresa T. Pizarro

Immunity（2024）

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Abstract
How commensals influence intestinal immunity is incompletely understood. In this issue of Immunity, Eshleman et al. demonstrate that microbiota-derived butyrate restrains tuft cell development via HDAC3 modulation in intestinal epithelial cells, showing how microbial metabolites impact intestinal type 2 immunity.
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